The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.

@article{Ali2007TheAE,
  title={The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.},
  author={Badreldin H Ali and Mansour S. Al Moundhri and M Tag Eldin and Abderrahim Nemmar and Musbah O. M. Tanira},
  journal={Fundamental & clinical pharmacology},
  year={2007},
  volume={21 5},
  pages={547-53}
}
Pathogenesis of nephrotoxicity of the synthetic anticancer drug cisplatin (CP) involves generation of reactive oxygen species and free radicals in the kidney cortex, and cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid (OTC) has been confirmed to have a strong antioxidant action. Therefore, in the present work, we aimed at testing the possible protective or palliative effect of OTC on CP nephrotoxicity in rats. OTC was given at an oral dose of 150 mg/kg/day for 7 days. On day 7, some of… CONTINUE READING