The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.

Abstract

Pathogenesis of nephrotoxicity of the synthetic anticancer drug cisplatin (CP) involves generation of reactive oxygen species and free radicals in the kidney cortex, and cysteine prodrug l-2-oxothiazolidine-4-carboxylic acid (OTC) has been confirmed to have a strong antioxidant action. Therefore, in the present work, we aimed at testing the possible… (More)

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@article{Ali2007TheAE, title={The ameliorative effect of cysteine prodrug L-2-oxothiazolidine-4-carboxylic acid on cisplatin-induced nephrotoxicity in rats.}, author={Badreldin H Ali and Mansour S. Al Moundhri and M H Tag Eldin and Abderrahim Nemmar and Musbah O. M. Tanira}, journal={Fundamental & clinical pharmacology}, year={2007}, volume={21 5}, pages={547-53} }