The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice

@article{Liu2013TheAE,
  title={The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice},
  author={Xiaotong Liu and Sung In Hong and S. Park and June Bryan I. de la Pe{\~n}a and Haiyan Che and S. Yoon and Donghyun Kim and Jong Min Kim and Mudan Cai and V. Risbrough and M. Geyer and C. Shin and J. Cheong and Haeil Park and J. Lew and J. Ryu},
  journal={Archives of Pharmacal Research},
  year={2013},
  volume={36},
  pages={854-863}
}
We previously reported that oroxylin A, a γ-aminobutyric acid A (GABAA) receptor antagonist, ameliorates drugs-induced memory impairments. We synthesized several oroxylin A derivatives in efforts to find a substance that has pro-cognitive effects as well as improves sensorimotor gating. The aim of the present study is to investigate the effect of a novel oroxylin A derivative, 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one (DMPC), on pharmacological models of schizophrenia, which… Expand
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