The alternative sigma factor SigF of Mycobacterium smegmatis is required for survival of heat shock, acidic pH and oxidative stress.

@article{Gebhard2008TheAS,
  title={The alternative sigma factor SigF of Mycobacterium smegmatis is required for survival of heat shock, acidic pH and oxidative stress.},
  author={Susanne Gebhard and Anja H{\"u}mpel and Alexander D McLellan and Gregory M. Cook},
  journal={Microbiology},
  year={2008},
  volume={154 Pt 9},
  pages={
          2786-95
        }
}
The alternative sigma factor SigF of Mycobacterium tuberculosis has been characterized in detail as a general-stress, stationary-phase sigma factor involved in the virulence of the bacterium. While a homologous gene has been annotated in the genome of the fast-growing Mycobacterium smegmatis, little experimental evidence is available on the function of this gene. Here, we demonstrate that SigF of M. smegmatis is required for resistance to hydrogen peroxide, heat shock and acidic pH, but not for… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 44 REFERENCES

A stationary-phase stress-response sigma factor from Mycobacterium tuberculosis.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1996
VIEW 15 EXCERPTS
HIGHLY INFLUENTIAL

Efficient allelic exchange and transposon mutagenesis in Mycobacterium tuberculosis.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Mycobacterium tuberculosis sigF is part of a gene cluster with similarities to the Bacillus subtilis sigF and sigB operons.

  • Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL