The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development.

@article{Dejardin2006TheAN,
  title={The alternative NF-kappaB pathway from biochemistry to biology: pitfalls and promises for future drug development.},
  author={Emmanuel Dejardin},
  journal={Biochemical pharmacology},
  year={2006},
  volume={72 9},
  pages={1161-79}
}
The past two decades have led to a tremendous work on the transcription factor NF-kappaB and its molecular mechanisms of activation. The nuclear translocation of NF-kappaB is controlled by two main pathways: the classical and the alternative NF-kappaB pathways. The classical NF-kappaB pathway activates the IKK complex that controls the inducible degradation of most IkappaB family members that are IkappaBalpha, IkappaBbeta, IkappaBvarepsilon and p105. The alternative NF-kappaB pathway induces… CONTINUE READING
Highly Influential
This paper has highly influenced 13 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 152 extracted citations

NF-kappaB dimers in the regulation of neuronal survival.

International review of neurobiology • 2009
View 6 Excerpts
Highly Influenced

Manipulation of Non-canonical NF-κB Signaling by Non-oncogenic Viruses

Archivum Immunologiae et Therapiae Experimentalis • 2018
View 4 Excerpts
Highly Influenced

Anti-tumor activity of fucoidan is mediated by nitric oxide released from macrophages.

International journal of oncology • 2012
View 10 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…