The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-naïve depression patients

@article{Lai2015TheAI,
  title={The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-na{\"i}ve depression patients},
  author={Chien-Han Lai and Yu-Te Wu},
  journal={Brain Imaging and Behavior},
  year={2015},
  volume={10},
  pages={187 - 194}
}
This study surveyed the characteristics of the indicator for the synchrony of brain activities, regional homogeneity (ReHo), in patients who were diagnosed with major depressive disorder (MDD) without co-morbidities. Forty-four patients with MDD and twenty-seven normal controls were enrolled in our study. The ReHo outputs of patients and controls were compared by a nonparametric permutation-based method with global brain volume, age, and gender as covariates. In addition, the correlations… 

Identify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study

Abnormal right supramarginal, right precuneus, right lingual gyrus and left superior frontal lobe alterations were present only in patients with rMDD and not in healthy control, and thus may be used as a state marker of MDD.

Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI

The ReHo of brain areas that were related to mood regulation was changed in the first-episode, drug-naive adult patients with MDD, suggesting that depressedadult patients with different age-onset might have different pathological mechanism.

Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder

It is suggested that increased medulla-IPC functional connectivity may be related to over-activity or abnormal control of negative emotions in MDD, which provides a new insight for the neurobiology of MDD.

Major Depressive Disorder in Neuroimaging: What is Beyond Fronto-limbic Model?

  • Chien-Han Lai
  • Psychology, Biology
    Current Psychiatry Research and Reviews
  • 2019
This review will focus on the literature of fMRI studies in MDD with findings not in the fronto-limbic structures, and the importance of sensory detection, visuospatial function, language reception, motor response and emotional memories in these regions might provide the clues to understand the cognitive misinterpretations related to altered reception of outside information.