The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-naïve depression patients

@article{Lai2015TheAI,
  title={The alterations in regional homogeneity of parieto-cingulate and temporo-cerebellum regions of first-episode medication-na{\"i}ve depression patients},
  author={Chien-Han Lai and Yu-Te Wu},
  journal={Brain Imaging and Behavior},
  year={2015},
  volume={10},
  pages={187-194}
}
This study surveyed the characteristics of the indicator for the synchrony of brain activities, regional homogeneity (ReHo), in patients who were diagnosed with major depressive disorder (MDD) without co-morbidities. Forty-four patients with MDD and twenty-seven normal controls were enrolled in our study. The ReHo outputs of patients and controls were compared by a nonparametric permutation-based method with global brain volume, age, and gender as covariates. In addition, the correlations… 
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The regional homogeneity of cingulate-precuneus regions: The putative biomarker for depression and anxiety.
TLDR
The specific cingulates alterations might be a putative ReHo biomarker to differentiate MDD from PD in cingulate-precuneus background for ReHo alterations.
Regional homogeneity associated with overgeneral autobiographical memory of first-episode treatment-naive patients with major depressive disorder in the orbitofrontal cortex: A resting-state fMRI study.
TLDR
Patients with major depressive disorder exhibited extensive ReHo abnormalities in some brain regions, including the frontal, temporal, and occipital cortex, and ReHo value of the orbitofrontal cortex was negatively correlated with OGM scores in patients with MDD.
Altered brain function and clinical features in patients with first-episode, drug naïve major depressive disorder: A resting-state fMRI study
TLDR
It is suggested that the altered brain function in the default mode network (DMN) may be related to functional impairments in patients with first-episode, drug naïve major depressive disorder.
Aberrant brain regional homogeneity in first-episode drug-naïve patients with major depressive disorder: A voxel-wise meta-analysis.
TLDR
ReHo alterations in these brain regions are likely to reflect the core disease-related functional abnormalities, which are implicated in emotional dysregulation and cognitive impairment that are seen in the early stage of MDD.
Identify abnormalities in resting-state brain function between first-episode, drug-naive major depressive disorder and remitted individuals: a 3-year retrospective study
TLDR
Abnormal right supramarginal, right precuneus, right lingual gyrus and left superior frontal lobe alterations were present only in patients with rMDD and not in healthy control, and thus may be used as a state marker of MDD.
Common and distinct neural activities in frontoparietal network in first-episode bipolar disorder and major depressive disorder: Preliminary findings from a follow-up resting state fMRI study.
TLDR
Abnormal neural activities of frontoparietal network may provide common and distinct markers to affective disorders and scientific basis for further prediction researches of Affective disorders.
Identify changes of brain regional homogeneity in early and later adult onset patients with first-episode depression using resting-state fMRI
TLDR
The ReHo of brain areas that were related to mood regulation was changed in the first-episode, drug-naive adult patients with MDD, suggesting that depressedadult patients with different age-onset might have different pathological mechanism.
Increased Functional Connectivity Between Medulla and Inferior Parietal Cortex in Medication-Free Major Depressive Disorder
TLDR
It is suggested that increased medulla-IPC functional connectivity may be related to over-activity or abnormal control of negative emotions in MDD, which provides a new insight for the neurobiology of MDD.
Functional network-based statistics in depression: Theory of mind subnetwork and importance of parietal region.
TLDR
Functional connectivity of "theory of mind" subnetwork may be the core issue for pathophysiology in MDD.
Major Depressive Disorder in Neuroimaging: What is Beyond Fronto-limbic Model?
  • Chien-Han Lai
  • Medicine
    Current Psychiatry Research and Reviews
  • 2019
TLDR
This review will focus on the literature of fMRI studies in MDD with findings not in the fronto-limbic structures, and the importance of sensory detection, visuospatial function, language reception, motor response and emotional memories in these regions might provide the clues to understand the cognitive misinterpretations related to altered reception of outside information.
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References

SHOWING 1-10 OF 55 REFERENCES
Disrupted regional homogeneity in treatment-resistant depression: A resting-state fMRI study
TLDR
There was no correlation between the ReHo values in any brain region detected in the study and the patients' age, years of education, illness duration, HRSD total score and its symptom factors.
Decreased regional homogeneity in lingual gyrus, increased regional homogeneity in cuneus and correlations with panic symptom severity of first-episode, medication-naïve and late-onset panic disorder patients
TLDR
ReHo differences found in the left lingual gyrus and the right cuneus might suggest sensory and inhibitory dysfunction in first-episode, medication-naïve, late-onset patients with PD.
Comparative study of regional homogeneity in schizophrenia and major depressive disorder
  • J. Chen, Yong Xu, +4 authors Qi Xu
  • Medicine
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2013
TLDR
This study suggests that the altered ReHo in the superior frontal and temporal gyrus may be specific for schizophrenia rather than MDD, and a left‐less‐than‐right asymmetry activation pattern may exist in the resting‐state superior frontal gyrus in schizophrenia.
Is there a cerebellar compensatory effort in first-episode, treatment-naive major depressive disorder at rest?
TLDR
The findings suggest that increased cerebellar activity at resting state may be a disease state phenomenon but not a compensatory response to the dysfunction of the default mode network (DMN) in MDD.
Decreased regional homogeneity in insula and cerebellum: A resting-state fMRI study in patients with major depression and subjects at high risk for major depression
TLDR
Compared with the control group, subjects with MDD and those at high risk for MDD exhibited significantly decreased ReHo in the right insula and in the left cerebellum, suggesting abnormalities in certain brain areas may play an important role in the pathophysiology of depression.
Alterations in Regional Homogeneity of Spontaneous Brain Activity in Late-Life Subthreshold Depression
TLDR
The results suggest that the regional activity coherence was changed in the resting brain of StD subjects, and that these alterations may serve as potential markers for the early detection ofStD in late-life depression.
Surface-Based Regional Homogeneity in First-Episode, Drug-Naïve Major Depression: A Resting-State fMRI Study
TLDR
The decreased surface-based ReHo in the left insula in MDD may lead to the abnormal top-down cortical-limbic regulation of emotional and cognitive information in the brain functional activity differences between first-episode, drug-naïve MDD patients and healthy controls.
Abnormal neural activity in the patients with remitted geriatric depression: a resting-state functional magnetic resonance imaging study.
TLDR
This study reveals that RGD is associated with abnormal activity of certain brain regions, which are believed to be involved in the psychopathology and pathophysiology of executive function in remitted geriatric depression.
Early brain changes associated with psychotherapy in major depressive disorder revealed by resting-state fMRI: evidence for the top-down regulation theory.
  • Xiaolan Huang, Peiyu Huang, +5 authors P. Xie
  • Psychology, Medicine
    International journal of psychophysiology : official journal of the International Organization of Psychophysiology
  • 2014
TLDR
The changes in regional homogeneity induced by guided imagery therapy demonstrate that this method of psychotherapy takes effect through a "top-down" mechanism.
Regional homogeneity in depression and its relationship with separate depressive symptom clusters: a resting-state fMRI study.
TLDR
The findings indicated abnormal brain activity was distributed extensively in depressed patients during resting state, and some symptom domains of depression are separately related to specific abnormal patterns of brain activity.
...
1
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