The alteration of sister chromatid exchange frequencies in Behçet's disease with and without HLA‐B51

  title={The alteration of sister chromatid exchange frequencies in Behçet's disease with and without HLA‐B51},
  author={Mevlit Ikbal and Mehmet Mahir Atasoy and İbrahim Pirim and Cihangir Aliaǧaoǧlu and Saliha Karatay and Teoman Erdem},
  journal={Journal of the European Academy of Dermatology and Venereology},
  • M. Ikbal, M. Atasoy, T. Erdem
  • Published 1 February 2006
  • Medicine, Biology
  • Journal of the European Academy of Dermatology and Venereology
Background  The analysis of sister chromatid exchange (SCE) is a cytogenetic technique used to show DNA damage as a result of an exchange of DNA fragments between sister chromatids. It is known that there is an increased SCE frequency in Behçet's disease (BD). 

Sister chromatid exchange and micronucleus studies in patients with Behçet’s disease

By counting sister chromatid exchange (SCE) and micronucleus frequencies, whether DNA damage have an effect on the pathogenesis of Behçet’s disease was determined.

Assessment of genotoxicity associated with Behcet’s disease using sister-chromatid exchange assay: vitamin E versus mitomycin C

Genotoxicity associated with BD can be overcome by treatment with vitamin E, and lymphocytes of BD have normal sensitivity to the mutagenic agent MMC, suggesting similar sensitivity of BD lymphocytes and control ones to MMC.

Micronucleus Analysis in Behçet ’ s Disease With and Without HLA-B 51 HLA-B 51

Investigating whether human leucocyte antigen (HLA)-B51-positive patients had higher MN frequency than those without HLA-B51 revealed that there was a significant association between elevated MN frequency and existence of HLA -B51 in patients with BD.

HLA-B51 gene and its expression in association with Behçet’s Disease in Denizli Province of Turkey

According to the results, there did not observe any association in between HLA-B51 gene, its polymorphism, expression and BD patients.

Cytogenetic study of the effect of Schistosoma mansoni infection on human peripheral blood lymphocytes and the role of β-carotene and vitamin E in modulating this effect

The use of the antioxidants β-carotene and vitamin E can be considered a promising approach not only toward inhibiting the genetic damage of schistosomiasis but also as prophylactic agents against infection with S mansoni.


Pesticides are chemical agents widely used by humans to protect the crops and livestock from nocive organisms as pests and vectors highly important in public health as well as in domestic

Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation

It is determined that Zscan4, in combination with the Yamanaka factors, not only remarkably reduced the DDR but also markedly promoted the efficiency of iPS cell generation, providing the first demonstration that maintaining genomic stability during reprogramming promotes the generation of high quality iPS cells.



Sister chromatid exchange frequencies in patients with scleroderma and their relatives.

It is observed that the SCE frequencies in blood lymphocytes of patients with scleroderma and their relatives do not differ from those of controls.

Chromosome aberration in lymphocytes from Behçet's disease.

The data suggested that the effect of treatment with colchicine or anticancer medication was one of the causes of the chromosome aberration observed in some BD lymphocytes.

Close association of HLA-Bw51 with Behçet's disease.

It seems likely that the susceptibility genes to Behçet's disease closely linked to HLA-Bw51 may have been spread by the old nomadic tribes or the Turks via the Silk Route.

Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing

It has been suggested that the SCE-technique should be considered as a valuable additional method for cytogenetic mutagenicity testing, which is not adequate to replace the classical methods of analysis of structural chromosome damage.

New Giemsa method for the differential staining of sister chromatids

If human lymphocytes1 or Chinese hamster2 cells are treated with the base analogue 5-bromodeoxyuridine in the latter part of the S period, Giemsa stained chromosomes exhibit a pattern of condensed and extended segments along their length, allowing the identification of the two chromatids, and the observation of sister chromatid exchanges (SCEs) without recourse to autoradiography.

Sister chromatid exchange formation.

  • S. Latt
  • Biology
    Annual review of genetics
  • 1981
The search for evidence of SCEs at a MOLECULAR level and the enzymology of seE Formation and the relationships to DNA Replication Fork are described.

Immunogenetic studies of Behçet's disease.

Current data on genetic factors involved in the development of Behçet's disease are reviewed and it is believed that many important genes exist in the region located between the TNF and HLA-B or Hla-C genes, including the MIC, PERB, and NOB genes.

Molecular genetics (HLA) of Behçet's disease.

The results suggest the possibility of a primary association of BD with MICA rather than HLA-B, and the genetic structure of the MICA gene was clarified, and a triplet repeat microsatellite polymorphism of (GCT/AGC)n in the transmebrane (TM) region was found.