The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients.

@article{Shibata2013TheAO,
  title={The alteration of hypoxia inducible factor-1 (HIF-1) and its target genes in mood disorder patients.},
  author={Tomohiko Shibata and Hirotaka Yamagata and Shusaku Uchida and Koji Otsuki and Teruyuki Hobara and Fumihiro Higuchi and Naoko Abe and Yoshifumi Watanabe},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={2013},
  volume={43},
  pages={222-9}
}
Recent studies suggest that the dysfunction of neural plasticity is associated with mood disorders. Hypoxia-inducible factor-1 (HIF-1), which is a transcriptional activator of vascular endothelial growth factor (VEGF), activates the cellular response to hypoxia. HIF-1 is ubiquitously expressed in all cells, including peripheral leukocytes. However, little is known about the role of HIF-1 in mood disorder. In the present study, we investigated the mRNA expression levels of HIF-1 (α and β) and… CONTINUE READING
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