The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors

@article{Lee2008TheAO,
  title={The alteration of enterochromaffin cell, mast cell, and lamina propria T lymphocyte numbers in irritable bowel syndrome and its relationship with psychological factors},
  author={Kwang Jae Lee and Yeong Bae Kim and Jang Hee Kim and Hoek Chun Kwon and Dong Kyu Kim and Sung Won Cho},
  journal={Journal of Gastroenterology and Hepatology},
  year={2008},
  volume={23}
}
Background/Aims:  Psychological factors and subtle histopathological changes have been implicated in irritable bowel syndrome (IBS). The aims of the present study were to investigate whether the numbers of enterochromaffin (EC) cells, mast cells, and lamina propria T lymphocytes are altered in IBS, and evaluate the relationship of such alterations with psychological factors. 
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The traditional paradigm of IBS as a ‘‘functional’’ disorder may be changing with the possibility of an underlying neuro-immune interaction increasingly being considered.
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  • 2016
TLDR
Investigation of how aging affects afferent sensitivity and neuro‐immune association in the human bowel finds an abnormal interplay between mast cells, enterochromaffin, and afferent nerves contribute to nociception in gastrointestinal disorders.
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There are indications that give reason to believe patients with Irritable Bowel Syndrome have "low-grade intestinal inflammation", and the increase in T-lymphocytes and mast cells has been associated with disorders found in IBS such as the communication between the intestine and the nervous system, the increased in intestinal permeability and changes in the microbiota.
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It is suggested that analysis of immune cells and IELs in intestinal biopsies might be an appropriate method for diagnosis of IBS.
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  • R. Iliaz, F. Akyüz, S. Kaymakoğlu
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    The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • 2018
TLDR
IBS and its subgroups showed lower immune cell counts than the controls in this study, indicating that there is no significant mucosal inflammation in homogeneous groups of patients with IBS.
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TLDR
Modern data on morphological changes in the intestinal mucosa in patients with irritable bowel syndrome is presented and it is shown that this pathology has an unusual low-grade inflammation.
Mast Cell May Be the Master Key to Solve the Mystery of Pathogenesis of Irritable Bowel Syndrome
  • H. Yoon
  • Biology, Medicine
    Gut and liver
  • 2016
TLDR
The authors found that mRNA expression of tryptase and PAR-2 was significantly elevated in the patients with IBS compared to the control, and the elevation of all neuropeptides in IBS-D only well corresponds with the results of some studies which showed mast cell hyperplasia is more common in Ibs-D.
The role of mast cells in functional GI disorders
TLDR
The role of mucosal mast cells in the gastrointestinal tract is discussed with a specific focus on recent advances in disease mechanisms and clinical management in irritable bowel syndrome and functional dyspepsia.
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