The alphabeta T cell receptor is an anisotropic mechanosensor.

  title={The alphabeta T cell receptor is an anisotropic mechanosensor.},
  author={Sun Taek Kim and Koh Takeuchi and Zhen-yu J Sun and Maki Touma and Carlos E. Castro and Amr Fahmy and Matthew J. Lang and Gerhard Wagner and Ellis L. Reinherz},
  journal={The Journal of biological chemistry},
  volume={284 45},
Thymus-derived lymphocytes protect mammalian hosts against virus- or cancer-related cellular alterations through immune surveillance, eliminating diseased cells. In this process, T cell receptors (TCRs) mediate both recognition and T cell activation via their dimeric alphabeta, CD3 epsilon gamma, CD3 epsilon delta, and CD3 zeta zeta subunits using an unknown structural mechanism. Here, site-specific binding topology of anti-CD3 monoclonal antibodies (mAbs) and dynamic TCR quaternary change… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 65 extracted citations

Mechanical regulation of T-cell functions.

Immunological reviews • 2013
View 7 Excerpts
Highly Influenced

Platelet integrins exhibit anisotropic mechanosensing and harness piconewton forces to mediate platelet aggregation.

Proceedings of the National Academy of Sciences of the United States of America • 2018
View 1 Excerpt

Similar Papers

Loading similar papers…