The alphabeta T cell receptor is an anisotropic mechanosensor.

@article{Kim2009TheAT,
  title={The alphabeta T cell receptor is an anisotropic mechanosensor.},
  author={Sun Taek Kim and Koh Takeuchi and Zhen-yu J Sun and Maki Touma and Carlos E. Castro and Amr Fahmy and Matthew J. Lang and Gerhard Wagner and Ellis L. Reinherz},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 45},
  pages={31028-37}
}
Thymus-derived lymphocytes protect mammalian hosts against virus- or cancer-related cellular alterations through immune surveillance, eliminating diseased cells. In this process, T cell receptors (TCRs) mediate both recognition and T cell activation via their dimeric alphabeta, CD3 epsilon gamma, CD3 epsilon delta, and CD3 zeta zeta subunits using an unknown structural mechanism. Here, site-specific binding topology of anti-CD3 monoclonal antibodies (mAbs) and dynamic TCR quaternary change… CONTINUE READING

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