The alphabet of intrinsic disorder: I. Act like a Pro: On the abundance and roles of proline residues in intrinsically disordered proteins.

@article{Theillet2013TheAO,
  title={The alphabet of intrinsic disorder: I. Act like a Pro: On the abundance and roles of proline residues in intrinsically disordered proteins.},
  author={François-Xavier Theillet and Lajos Kalm{\'a}r and Peter Tompa and Kyou-Hoon Han and Philipp Selenko and A. Keith Dunker and Gary W. Daughdrill and Vladimir N. Uversky},
  journal={Intrinsically disordered proteins},
  year={2013},
  volume={1 1},
  pages={e24360}
}
A significant fraction of every proteome is occupied by biologically active proteins that do not form unique three-dimensional structures. These intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) have essential biological functions and are characterized by extensive structural plasticity. Such structural and functional behavior is encoded in the amino acid sequences of IDPs/IDPRs, which are enriched in disorder-promoting residues and depleted in order-promoting residues. In fact… CONTINUE READING
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