• Medicine
  • Published in
    Molecular biology and…
    2007

The alphaD-globin gene originated via duplication of an embryonic alpha-like globin gene in the ancestor of tetrapod vertebrates.

@article{Hoffmann2007TheAG,
  title={The alphaD-globin gene originated via duplication of an embryonic alpha-like globin gene in the ancestor of tetrapod vertebrates.},
  author={Federico G. Hoffmann and Jay F Storz},
  journal={Molecular biology and evolution},
  year={2007},
  volume={24 9},
  pages={
          1982-90
        }
}
Gene duplication is thought to play an important role in the co-option of existing protein functions to new physiological pathways. The globin superfamily of genes provides an excellent example of the kind of physiological versatility that can be attained through the functional and regulatory divergence of duplicated genes that encode different subunit polypeptides of the tetrameric hemoglobin protein. In contrast to prevailing views about the evolutionary history of the alpha-globin gene… CONTINUE READING

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