The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.

@article{Dehart2008TheAI,
  title={The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel.},
  author={Gregory W Dehart and Taihao Jin and Diane E. McCloskey and Anthony E. Pegg and Dean Sheppard},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 20},
  pages={7188-93}
}
The alpha9beta1 integrin accelerates cell migration through binding of spermidine/spermine acetyltransferase (SSAT) to the alpha9 cytoplasmic domain. We now show that SSAT enhances alpha9-mediated migration specifically through catabolism of spermidine and/or spermine. Because spermine and spermidine are effective blockers of K(+) ion efflux through inward-rectifier K(+) (Kir) channels, we examined the involvement of Kir channels in this pathway. The Kir channel inhibitor, barium, or knockdown… CONTINUE READING

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