The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders

@inproceedings{CapVlez2018TheAR,
  title={The alpha7-nicotinic receptor contributes to gp120-induced neurotoxicity: implications in HIV-associated neurocognitive disorders},
  author={Coral M Cap{\'o}-V{\'e}lez and Bryan Morales-Vargas and Aurian P. Garc{\'i}a-Gonz{\'a}lez and Jos{\'e} G Grajales-Reyes and Manuel Delgado-V{\'e}lez and Bismark Madera and Carlos Alberto B{\'a}ez-Pag{\'a}n and Orestes Quesada and Jos{\'e} Antonio Lasalde-Dominicci},
  booktitle={Scientific Reports},
  year={2018}
}
Currently, there are no specific therapies to treat HIV-1 associated neurocognitive disorders (HAND). The HIV-1 envelope, gp120, induces neuropathological changes similar to those in HAND patients; furthermore, it triggers an upregulation of the α7-nicotinic acetylcholine receptor (α7-nAChR), facilitating intracellular calcium overload and neuronal cell death. Using a gp120IIIB-transgenic mouse (gp120-tgm) model, we demonstrate that α7-nAChRs are upregulated on striatal neurons. Activation of… CONTINUE READING
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