The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin.

@article{Goldfinger1999TheAL,
  title={The alpha3 laminin subunit, alpha6beta4 and alpha3beta1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin.},
  author={Lawrence E. Goldfinger and Susan B Hopkinson and Gregory W Dehart and Sherry Stine Collawn and John Robert Couchman and Jonathan C R Jones},
  journal={Journal of cell science},
  year={1999},
  volume={112 ( Pt 16)},
  pages={2615-29}
}
Previously, we demonstrated that proteolytic processing within the globular domain of the alpha3 subunit of laminin-5 (LN5) converts LN5 from a cell motility-inducing factor to a protein complex that can trigger the formation of hemidesmosomes, certain cell-matrix attachment sites found in epithelial cells. We have prepared a monoclonal antibody (12C4) whose epitope is located toward the carboxy terminus of the globular domain of the alpha3 laminin subunit. This epitope is lost from the alpha3… CONTINUE READING