The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.

@article{Dostanic2005TheAO,
  title={The alpha2-isoform of Na-K-ATPase mediates ouabain-induced hypertension in mice and increased vascular contractility in vitro.},
  author={Iva Dostanic and Richard J. Paul and John N. Lorenz and Steven Theriault and James W Van Huysse and Jerry B. Lingrel},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={288 2},
  pages={H477-85}
}
Although ouabain is known to induce hypertension, the mechanism of how this cardiac glycoside affects blood pressure is uncertain. The present study demonstrates that the alpha2-isoform of the Na-K-ATPase mediates the pressor effects of ouabain in mice. To accomplish this, we analyzed the effect of ouabain on blood pressure in wild-type mice, where the… CONTINUE READING