The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers.

@article{Mijatovic2007TheAS,
  title={The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers.},
  author={Tatjana Mijatovic and Isabelle Roland and Eric Van Quaquebeke and Bj{\"o}rn Nilsson and Anne Mathieu and Frank Van Vynckt and Francis Darro and Gustavo Blanco and Vincenzo Facchini and R{\'o}bert Kiss},
  journal={The Journal of pathology},
  year={2007},
  volume={212 2},
  pages={170-9}
}
With an overall 5 year survival rate as low as 15% for non-small cell lung cancer (NSCLC), even with surgical intervention and the use of newer molecules in adjuvant chemotherapy, there is an urgent need for new biological targets and associated novel anti-cancer agents. The present study was undertaken to evaluate the potential of the Na(+)/K(+)-ATPase alpha1 subunit as a novel target in NSCLC and revealed that alpha1 expression is markedly higher in a significant proportion of NSCLC clinical… CONTINUE READING
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