The alpha1 subunit of laminin-1 promotes the development of neurons by interacting with LBP110 expressed by neural crest-derived cells immunoselected from the fetal mouse gut.

@article{Chalazonitis1997TheAS,
  title={The alpha1 subunit of laminin-1 promotes the development of neurons by interacting with LBP110 expressed by neural crest-derived cells immunoselected from the fetal mouse gut.},
  author={Alcm{\`e}ne Chalazonitis and Virginia M. Tennyson and Maura C. Kibbey and Taube P Rothman and Michael David Gershon},
  journal={Journal of neurobiology},
  year={1997},
  volume={33 2},
  pages={118-38}
}
A plasmalemmal protein, LBP110, which binds to the alpha1 chain of laminin-1, is acquired by the neural crest-derived precursors of enteric neurons after they colonize the gut. We tested the hypothesis that laminin-1 interacts with LBP110 to promote enteric neuronal development. The effects of laminin-1 on neuronal development were studied in cultures of cells immunoselected from fetal mouse gut (E14-15) with antibodies to LBP110 or p75NTR, a marker for enteric crest-derived cells. No matter… CONTINUE READING

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