The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration.

@article{Greenwell2009TheAA,
  title={The alpha1 adrenergic receptor antagonist prazosin reduces heroin self-administration in rats with extended access to heroin administration.},
  author={Thomas N Greenwell and Brendan Walker and Pietro Cottone and Eric Zorrilla and George F. Koob},
  journal={Pharmacology, biochemistry, and behavior},
  year={2009},
  volume={91 3},
  pages={295-302}
}
Previous studies have reported that noradrenergic antagonists alleviate some of the symptoms of opiate withdrawal and dependence. Clinical studies also have shown that modification of the noradrenergic system may help protect patients from relapse. The present study tested the hypothesis that a dysregulated noradrenergic system has motivational significance in heroin self-administration of dependent rats. Prazosin, an alpha1-adrenergic antagonist (0.5, 1.0, 1.5 and 2.0 mg/kg, i.p.), was… CONTINUE READING
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