The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.

@article{Codina1987TheAS,
  title={The alpha subunit of the GTP binding protein Gk opens atrial potassium channels.},
  author={Juan Codina and Atsuko Yatani and Dominique Grenet and Arthur M. Brown and Lutz Birnbaumer},
  journal={Science},
  year={1987},
  volume={236 4800},
  pages={442-5}
}
Guanine nucleotide binding (G) proteins (subunit composition alpha beta gamma) dissociate on activation with guanosine triphosphate (GTP) analogs and magnesium to give alpha-guanine nucleotide complexes and free beta gamma subunits. Whether the opening of potassium channels by the recently described Gk in isolated membrane patches from mammalian atrial myocytes was mediated by the alpha k subunit or beta gamma dimer was tested. The alpha k subunit was found to be active, while the beta gamma… CONTINUE READING

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