The alpha-subunit of protein prenyltransferases is a member of the tetratricopeptide repeat family.

@article{Zhang1999TheAO,
  title={The alpha-subunit of protein prenyltransferases is a member of the tetratricopeptide repeat family.},
  author={Heidi Zhang and Nick V. Grishin},
  journal={Protein science : a publication of the Protein Society},
  year={1999},
  volume={8 8},
  pages={1658-67}
}
Lipidation catalyzed by protein prenyltransferases is essential for the biological function of a number of eukaryotic proteins, many of which are involved in signal transduction and vesicular traffic regulation. Sequence similarity searches reveal that the alpha-subunit of protein prenyltransferases (PTalpha) is a member of the tetratricopeptide repeat (TPR) superfamily. This finding makes the three-dimensional structure of the rat protein farnesyltransferase the first structural model of a TPR… CONTINUE READING