The alpha-macroglobulins from rat plasma: structure, plasma clearance and endocytosis of complexes with subtilisin.

Rat alpha 2M was isolated from plasma of animals which had been treated with stress hormones. Polyacrylamide-gel electrophoresis of the reduced protein in the presence of sodium dodecyl sulfate showed a band with a Mr of 175,000. In a previous work (Biochem. J. 226, 75-84, 1985) we had found that rat alpha 1M consists of two types of subunits with Mr's of… (More)