The alpha-hemoglobin stabilizing protein and expression of unstable alpha-Hb variants.

  title={The alpha-hemoglobin stabilizing protein and expression of unstable alpha-Hb variants.},
  author={C. Vasseur and {\'E}lisa Domingues-Hamdi and Thomas Brillet and M. Marden and V. Baudin-Creuza},
  journal={Clinical biochemistry},
  volume={42 18},
  • C. Vasseur, Élisa Domingues-Hamdi, +2 authors V. Baudin-Creuza
  • Published 2009
  • Chemistry, Medicine
  • Clinical biochemistry
  • OBJECTIVES To determine the role of the alpha-hemoglobin stabilizing protein (AHSP) in the clinical expression of alpha-hemoglobin (alpha-Hb) variants described as unstable, ten alpha chain variants have been studied with their chaperone. AHSP specifically binds free alpha-Hb to form a soluble heterodimer until it is replaced by the beta-Hb partner. In this way, AHSP prevents the precipitation of free alpha chains which might damage the membrane of erythrocyte. AHSP specifically recognizes the… CONTINUE READING
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