The alpha-gal story: lessons learned from connecting the dots.

  title={The alpha-gal story: lessons learned from connecting the dots.},
  author={John W. Steinke and Thomas A Platts-Mills and Scott P. Commins},
  journal={The Journal of allergy and clinical immunology},
  volume={135 3},
  pages={589-96; quiz 597}
Anaphylaxis is a severe allergic reaction that can be rapidly progressing and fatal, and therefore establishing its cause is pivotal to long-term risk management. Our recent work has identified a novel IgE antibody response to a mammalian oligosaccharide epitope, galactose-alpha-1,3-galactose (alpha-gal). IgE to alpha-gal has been associated with 2 distinct forms of anaphylaxis: (1) immediate-onset anaphylaxis during first exposure to intravenous cetuximab and (2) delayed-onset anaphylaxis 3 to… CONTINUE READING
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