The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex

@article{Karlsson1992TheAC,
  title={The alpha chain gene of H-2O has an unexpected location in the major histocompatibility complex},
  author={L. K. J. Karlsson and Per A. Peterson},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={176},
  pages={477 - 483}
}
A previously unknown major histocompatibility complex class II molecule consisting of the beta chain encoded by the H-2Ob gene and an unknown alpha chain was recently described. We now report that the alpha chain occurs in two allelic forms distinguished by charge difference. Using inbred recombinant mouse strains we were able to map the H-2Oa gene to a location between the A.TL and B10.MBR recombination points. Cosmids covering this region were used to isolate the gene. Sequence analysis… CONTINUE READING

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