The alpha carbon oxidation of some phencyclidine analogues by rat tissue and its pharmacological implications.

1. The metabolism of phencyclidine (PCP) and three congeners, differing in the structure of the amine moiety, by liver microsomes from phenobarbital-pretreated rats, was determined. 2. The metabolites generated by sequential oxidation of the two carbons alpha to the nitrogen were measured for PCP and its diethyl analogue (PCDE). 3. Alpha hydroxylation was a… CONTINUE READING