The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity.

@article{Morini2000TheA3,
  title={The alpha 3 beta 1 integrin is associated with mammary carcinoma cell metastasis, invasion, and gelatinase B (MMP-9) activity.},
  author={Monica Morini and Marcella Mottolese and Nicoletta Ferrari and F Ghiorzo and Simonetta Buglioni and Roberta Mortarini and Douglas M Noonan and Pier Giorgio Natali and Adriana Albini},
  journal={International journal of cancer},
  year={2000},
  volume={87 3},
  pages={336-42}
}
The alpha 3 beta 1 integrin is elevated in several types of metastatic tumor and has been associated with increased migration and invasion. Our analysis of a series of mammary carcinomas of different histotypes and their corresponding metastases demonstrated significantly increased expression of alpha 3 beta 1 in the tumor metastases. We therefore studied alpha 3 beta 1 expression of several human breast carcinoma cell lines and its association with the invasive phenotype. The MDA-MB-231 cell… CONTINUE READING