The alpha-2 isomer of the sodium pump is inhibited by calcium at physiological levels.

@article{McGeoch1990TheAI,
  title={The alpha-2 isomer of the sodium pump is inhibited by calcium at physiological levels.},
  author={Julie E. M. McGeoch},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={173 1},
  pages={99-105}
}
The inhibition of the (Na,K)ATPase by calcium was investigated in plasma membrane preparations of rat axolemma, skeletal muscle and kidney outer medulla. Ouabain titration curves demonstrated that physiological calcium (0.08-5 microM) inhibited mainly the high affinity alpha 2 isomer. In axolemma all the (Na,K)ATPase had high ouabain affinity and calcium inhibited 40-50% of the activity with a Ki of 1.9 +/- 0.9 x 10(-7) M. In skeletal muscle high and low ouabain affinity components were present… CONTINUE READING

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