The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.

Abstract

The present study attempted to identify an alpha-2 agonist that could improve working memory in aged nonhuman primates without the marked hypotensive and sedative side effects produced by clonidine. Toward this end, the hypotensive, sedative, and memory-altering properties of the alpha-2 adrenergic agonists, B-HT920 and guanfacine, were compared with… (More)

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Cite this paper

@article{Arnsten1988TheAA, title={The alpha-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects: evidence for alpha-2 receptor subtypes.}, author={Amy F. T. Arnsten and J. X. Cai and Patricia S. Goldman-Rakic}, journal={The Journal of neuroscience : the official journal of the Society for Neuroscience}, year={1988}, volume={8 11}, pages={4287-98} }