The alpha 1-antitrypsin gene is expressed in a human intestinal epithelial cell line.

@article{Perlmutter1989TheA1,
  title={The alpha 1-antitrypsin gene is expressed in a human intestinal epithelial cell line.},
  author={David H. Perlmutter and James D Daniels and H S Auerbach and K De Schryver-Kecskemeti and Harland S. Winter and David H. Alpers},
  journal={The Journal of biological chemistry},
  year={1989},
  volume={264 16},
  pages={9485-90}
}
alpha 1-Antitrypsin (alpha 1-AT) is considered a typical plasma protein and a prototype of the serine proteinase inhibitor (serpin) family. It is synthesized in hepatocytes and, to a lesser extent, in macrophages. In this study we show that the alpha 1-AT gene is also expressed in human intestine and in a human colonic epithelial tumor cell line, Caco2. A single 1.6-kilobase alpha 1-AT-specific mRNA is present in jejunum and in Caco2 cells. It is identical in apparent size to that present in… CONTINUE READING

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