The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study.

@article{Shorter2013TheAA,
  title={The alpha-1 adrenergic antagonist doxazosin for treatment of cocaine dependence: A pilot study.},
  author={Daryl I Shorter and Jan A Lindsay and Thomas R. Kosten},
  journal={Drug and alcohol dependence},
  year={2013},
  volume={131 1-2},
  pages={66-70}
}
BACKGROUND Medications decreasing central noradrenergic activity have been associated with attenuation of cocaine effects. AIMS This pilot study examined the efficacy of doxazosin versus placebo for reducing cocaine use in treatment-seeking cocaine dependent persons. METHODS We screened 108 cocaine dependent subjects and assigned 35 participants to receive either doxazosin (8mg/day) or placebo for 13 weeks. Participants were titrated on the study medication according to two different… CONTINUE READING

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