The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.

@article{Goodman2010TheAI,
  title={The alpha/beta interferon receptor provides protection against influenza virus replication but is dispensable for inflammatory response signaling.},
  author={Alan G Goodman and Hui Zeng and Sean C. Proll and Xinxia Peng and Cristian Cill{\'o}niz and Victoria S. Carter and Marcus J. Korth and Terrence M. Tumpey and Michael G. Katze},
  journal={Journal of virology},
  year={2010},
  volume={84 4},
  pages={
          2027-37
        }
}
The innate immune response provides the first line of defense against foreign pathogens by responding to molecules that are a signature of a pathogenic infection. Certain RNA viruses, such as influenza virus, produce double-stranded RNA as an intermediate during the replication life cycle, which activates pathogen recognition receptors capable of inducing interferon production. By engaging interferon receptors, interferon activates the JAK-STAT pathway and results in the positive feedback of… CONTINUE READING
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