The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.

@article{Schramm2001TheAR,
  title={The alpha(2a)-adrenergic receptor plays a protective role in mouse behavioral models of depression and anxiety.},
  author={Nicole L. Schramm and Michael P. McDonald and Lee E. Limbird},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 13},
  pages={4875-82}
}
The noradrenergic system is involved in the regulation of many physiological and psychological processes, including the modulation of mood. The alpha(2)-adrenergic receptors (alpha(2)-ARs) modulate norepinephrine release, as well as the release of serotonin and other neurotransmitters, and are therefore potential targets for antidepressant and anxiolytic drug development. The current studies were undertaken to examine the role of the alpha(2A) subtype of alpha(2)-AR in mouse behavioral models… CONTINUE READING
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