The allosteric binding sites of sulfotransferase 1A1.


Human sulfotransferases (SULTs) comprise a small, 13-member enzyme family that regulates the activities of thousands of compounds-endogenous metabolites, drugs, and other xenobiotics. SULTs transfer the sulfuryl-moiety (-SO3) from a nucleotide donor, PAPS (3'-phosphoadenosine 5'-phosphosulfate), to the hydroxyls and primary amines of acceptors. SULT1A1, a… (More)
DOI: 10.1124/dmd.114.061887


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@article{Cook2015TheAB, title={The allosteric binding sites of sulfotransferase 1A1.}, author={Ian T. Cook and Ting Wang and Charles N. Falany and Thomas S. Leyh}, journal={Drug metabolism and disposition: the biological fate of chemicals}, year={2015}, volume={43 3}, pages={418-23} }