The allele burden of JAK2 V617F can aid in differential diagnosis of Philadelphia Chromosome-Negative Myeloproliferative Neoplasm

@inproceedings{Park2013TheAB,
  title={The allele burden of JAK2 V617F can aid in differential diagnosis of Philadelphia Chromosome-Negative Myeloproliferative Neoplasm},
  author={Sang Hyuk Park and Hyun-sook Chi and Young-uk Cho and Seongsoo Jang and Chan Park},
  booktitle={Blood research},
  year={2013}
}
BACKGROUND We aimed to evaluate the feasibility of using the allele burden of Janus kinase 2 (JAK2) V617F as a criterion for discriminating 3 subtypes of Philadelphia chromosome-negative myeloproliferative neoplasm (Ph(-)MPN): polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). METHODS We collected 70 peripheral blood (PB) and 81 bone marrow (BM) samples from patients diagnosed with Ph(-)MPN. Real-time quantitative PCR (RQ-PCR) and Amplification Refractory… CONTINUE READING