The alarmin IL-33 is a notch target in quiescent endothelial cells.

@article{Sundlisaeter2012TheAI,
  title={The alarmin IL-33 is a notch target in quiescent endothelial cells.},
  author={Eirik Sundlisaeter and Reidunn J Edelmann and Johanna Hol and Jon Sponheim and Axel M K{\"u}chler and Miriam Weiss and Irina A Udalova and Kim S. Midwood and Monika Kasprzycka and Guttorm Haraldsen},
  journal={The American journal of pathology},
  year={2012},
  volume={181 3},
  pages={1099-111}
}
The molecular mechanisms that drive expression of the alarmin interleukin-33 (IL-33) in endothelial cells are unknown. Because nuclear IL-33 is a marker of endothelial cell quiescence (corroborated in this study by coexpression of cyclin-dependent kinase inhibitor p27(Kip1)), we hypothesized that Notch signaling might be involved in regulating IL-33 expression. Activation of Notch1 by immobilized Notch ligands was sufficient to induce nuclear IL-33 expression in cultured endothelial cells… CONTINUE READING

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