The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.

@article{Hirota2012TheAE,
  title={The airway epithelium nucleotide-binding domain and leucine-rich repeat protein 3 inflammasome is activated by urban particulate matter.},
  author={Jeremy A Hirota and Simon A Hirota and Stephanie Mary Warner and Dorota Stefanowicz and Furquan Shaheen and Paul L. Beck and Justin A. MacDonald and Tillie L. Hackett and Don D. Sin and Stephan van Eeden and Darryl A Knight},
  journal={The Journal of allergy and clinical immunology},
  year={2012},
  volume={129 4},
  pages={1116-25.e6}
}
BACKGROUND The airway epithelium is the first line of defense against inhaled insults and therefore must be capable of coordinating appropriate inflammatory and immune responses. OBJECTIVE We sought to test the hypothesis that the nucleotide-binding domain and leucine-rich repeat protein 3 (NLRP3) inflammasome, an intracellular danger-sensing complex, plays a critical role in airway epithelium-mediated immune responses to urban particulate matter (PM) exposure. METHODS In this study we (1… CONTINUE READING
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