The airway epithelium and arachidonic acid 15-lipoxygenase.

  title={The airway epithelium and arachidonic acid 15-lipoxygenase.},
  author={Elliott Sigal and Jay A. Nadel},
  journal={The American review of respiratory disease},
  volume={143 3 Pt 2},
Pulmonary epithelial cells may be primarily responsible for initiating or regulating inflammatory responses in the airways, in part by releasing chemical mediators. Among the most potent mediators of inflammation are the lipoxygenase metabolites of arachidonic acid, including the leukotrienes and other mono and dihydroxyeicosatetraenoic acids (HETES). The human airway epithelium contains significant 15-lipoxygenase activity. Although some biologic functions of 15-lipoxygenase metabolites are… CONTINUE READING