The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

@article{Ruegg1992TheAG,
  title={The agrin gene codes for a family of basal lamina proteins that differ in function and distribution},
  author={Markus A. Ruegg and Karl Wati-Keung Tsim and Sharon E. Horton and Stephan Kr{\"o}ger and Uel Jackson McMahan},
  journal={Neuron},
  year={1992},
  volume={8},
  pages={691-699}
}
We isolated two cDNAs that encode isoforms of agrin, the basal lamina protein that mediates the motor neuron-induced aggregation of acetylcholine receptors on muscle fibers at the neuromuscular junction. Both proteins are the result of alternative splicing of the product of the agrin gene, but unlike agrin, they are inactive in standard acetylcholine receptor aggregation assays. They lack one (agrin-related protein 1) or two (agrin-related protein 2) regions in agrin that are required for its… CONTINUE READING
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References

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The agrin hypothesis.

  • Cold Spring Harbor symposia on quantitative biology
  • 1990
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Motor neurons contain agrin-like molecules

  • The Journal of cell biology
  • 1988
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL