The aging suppressor klotho: a potential regulator of growth hormone secretion.

@article{Shahmoon2014TheAS,
  title={The aging suppressor klotho: a potential regulator of growth hormone secretion.},
  author={Shiri Shahmoon and Hadara Rubinfeld and Ido Wolf and Z R Cohen and Moshe Hadani and Ilan Shimon and Tami Rubinek},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2014},
  volume={307 3},
  pages={E326-34}
}
Klotho is a transmembranal protein highly expressed in the kidneys, choroid plexus, and anterior pituitary. Klotho can also be cleaved and shed and acts as a circulating hormone. Klotho-deficient mice (kl/kl mice) develop a phenotype resembling early aging. Several lines of evidence suggest a role for klotho in the regulation of growth hormone (GH) secretion. The kl/kl mice are smaller compared with their wild-type counterparts, and their somatotropes show reduced numbers of secretory granules… CONTINUE READING
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References

Publications referenced by this paper.
Showing 1-10 of 39 references

Central and peripheral actions of somatostatin on the growth hormone-IGF-I axis.

The Journal of clinical investigation • 2004
View 9 Excerpts
Highly Influenced

Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1-deficient mice.

The Journal of clinical investigation • 2004
View 9 Excerpts
Highly Influenced

Regulation of fibroblast growth factor-23 signaling by klotho.

The Journal of biological chemistry • 2006
View 6 Excerpts
Highly Influenced

Suppression of aging in mice by the hormone Klotho.

Science • 2005
View 7 Excerpts
Highly Influenced

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