The aging ovary--the poor granulosa cells.

  title={The aging ovary--the poor granulosa cells.},
  author={Carla Tatone and Fernanda Amicarelli},
  journal={Fertility and sterility},
  volume={99 1},
The development of a competent oocyte intimately depends on the maintenance of energetic homeostasis in the ovarian and follicular microenvironment. On this basis, it is very likely that the oocyte ages as the ovary ages. Starting from the molecular evidence for energy perturbations in the whole ovary, we review current knowledge on the involvement of endogenous highly reactive metabolites in follicle aging. The first part provides an update of recent findings that confirm the key role of… CONTINUE READING