The aging male project

  • Fand Saad Abstrak
  • Published 2012

Abstract

With an increasing Iift expectancy and a decreasing reproduction rate, the population structure changes. A Jenapharm R & D program investigates the endocrinology of aging men. In men, a decrease in production of sex steroids and other hormones with age can be observed. The typical patterns of daily rhythmicity become less distinct. This is part of a very complex picture in which not only isolated hormones are involved, but also the influence of hormones on each other. Many factors from the external and intemal environment mediated by neuroîransmitters constantly affect the highly sensitive hormonal balance. Therefore, aging has also been defned as "the gradual dysfunction of homeostatic processes". DecLining testosterone (T) Ievels are involveà ii'andropausal' symPloms in men: Ioss of libido, erectile dysfunction, insulin receptor resistance, obesity, osteoporosis, disîurbances of lipid metabolism, myocardial and circuLatory disturbances, impaired well-being and mood. Daîa are derivedfrom studies in hypo[onadal men treated by T replacement. In such parients under T treaîment libido increases, fat mass decreases, muscle strenth, bone mineral density and erythropoesis increase. Whether the symptoms of andropause in aging men could successfully be treated by T substitution remains to be investigated. Negative effects ofT, especially on the prostate and the cardiovascular system, are under discussion. There is increasing evidence that low T levels seem to be a riskfactorfor both the prostate and the cardiovascular system. Jenapharm's new testosterone undecanoate formulation for intramuscular injection can be administered every three months. T levels remain within the physiologic range. No supraphysiologic peaks occur. In women, estrogens have beneficial non-genital effects. Studies concentrate on s\nthetic estrogens for men withoul feminizing properties such (is gynecomastia and reduced rcsricular size. Several derivatives of 17alpha estradiol have been synthesized some of which show selectivity for the central neruous system. CNS effects have been demonstrated in female and male animals. Cardiovascular protection by estrogens has been shown in animal and human studies. Atherosclerotic plaque siae vos redttced after estrogen injections in choLesterol-fed rabbits. phytoestrogen-fed monkeys had lower total cholesterol and LDL cholesterol and higher HDL cholesterol. Apart from atherosclerotic lesions, coroutry artery vascular reactivi^* v'as improted. Some o-f iircse expeintental fndings v+'ere confrmed in human studies in postmenopausal women with and without estroqen ireôtmen:. ll'he:ker alL o.f the described eslrogenic effects can be seen in men remains to be investigated. (Med J Indones 2AO1; l0: 127-33) Keyw ords : a gin g, andropaus e. r e s t o s rc ra ne. e s tro e e ns Research and Development at Jmaphann Jerut Getmont

Cite this paper

@inproceedings{Abstrak2012TheAM, title={The aging male project}, author={Fand Saad Abstrak}, year={2012} }