The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback.

  title={The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback.},
  author={Johannes D. Veldhuis and Daniel M. Keenan and Peter Y Liu and A. Iranmanesh and Paul Y. Takahashi and Ajay X Nehra},
  journal={Molecular and cellular endocrinology},
  volume={299 1},
Aging results in insidious decremental changes in hypothalamic, pituitary and gonadal function. The foregoing three main anatomic loci of control are regulated by intermittent time-delayed signal exchange, principally via gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH) and testosterone/estradiol (Te/E(2)). A mathematical framework is required to embody these dynamics. The present review highlights integrative adaptations in the aging male hypothalamic-pituitary-gonadal axis, as… CONTINUE READING

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