The aging brain.

  title={The aging brain.},
  author={Bruce A. Yankner and Tao Lu and Patrick M. Loerch},
  journal={Annual review of pathology},
Aging is accompanied by cognitive decline in a major segment of the population and is the primary risk factor for Alzheimer's disease and other prevalent neurodegenerative disorders. Despite this central role in disease pathogenesis and morbidity, the aging of the brain has not been well understood at a molecular level. This review seeks to integrate what is known about age-related cognitive and neuroanatomical changes with recent advances in understanding basic molecular mechanisms that… CONTINUE READING