The aging Leydig cell: 1. Testosterone and adenosine 3',5'-monophosphate responses to gonadotropin stimulation in rats.

@article{Lin1980TheAL,
  title={The aging Leydig cell: 1. Testosterone and adenosine 3',5'-monophosphate responses to gonadotropin stimulation in rats.},
  author={T F Lin and Eisuke P. Murono and Juraj Osterman and Donald O. Allen and Howard R Nankin},
  journal={Steroids},
  year={1980},
  volume={35 6},
  pages={653-63}
}
Plasma testosterone levels before and after a single injection of hCG were significantly lower in 24-month old rats than 60--90 day old animals (p less than 0.001). Even with repeated hCG administration for three weeks, plasma testosterone levels of old rats could not be restored to levels present in unstimulated young rats. In response to in vitro LH and 8-bromo-cyclic AMP stimulation, purified young Leydig cells produced significantly higher amounts of testosterone than Leydig cells from old… CONTINUE READING