The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells.

@article{Konarkowska2006TheAP,
  title={The aggregation potential of human amylin determines its cytotoxicity towards islet beta-cells.},
  author={Barbara Konarkowska and Jacqueline F. Aitken and Joerg Kistler and Shaoping Zhang and Garth J S Cooper},
  journal={The FEBS journal},
  year={2006},
  volume={273 15},
  pages={3614-24}
}
Human amylin is a small fibrillogenic protein that is the major constituent of pancreatic islet amyloid, which occurs in most subjects with type 2 diabetes. There is evidence that it can elicit in vitro apoptosis in islet beta-cells, but the physical properties that underpin its cytotoxicity have not been clearly elucidated. Here we employed electron microscopy, thioflavin T fluorescence and CD spectroscopy to analyze amylin preparations whose cytotoxic potential was established by live-dead… CONTINUE READING

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