The ageing lens and cataract: a model of normal and pathological ageing.

@article{Michael2011TheAL,
  title={The ageing lens and cataract: a model of normal and pathological ageing.},
  author={Ralph Michael and Anthony John Bron},
  journal={Philosophical transactions of the Royal Society of London. Series B, Biological sciences},
  year={2011},
  volume={366 1568},
  pages={1278-92}
}
Cataract is a visible opacity in the lens substance, which, when located on the visual axis, leads to visual loss. Age-related cataract is a cause of blindness on a global scale involving genetic and environmental influences. With ageing, lens proteins undergo non-enzymatic, post-translational modification and the accumulation of fluorescent chromophores, increasing susceptibility to oxidation and cross-linking and increased light-scatter. Because the human lens grows throughout life, the lens… CONTINUE READING