The aged niche disrupts muscle stem cell quiescence

@inproceedings{Chakkalakal2012TheAN,
  title={The aged niche disrupts muscle stem cell quiescence},
  author={Joe V Chakkalakal and Kieran M. Jones and M Albert Basson and Andrew S. Brack},
  booktitle={Nature},
  year={2012}
}
The niche is a conserved regulator of stem cell quiescence and function. During ageing, stem cell function declines. To what extent and by what means age-related changes within the niche contribute to this phenomenon are unknown. Here we demonstrate that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity. We show in mice that relatively dormant aged… CONTINUE READING
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