The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor.

@article{Kordower1994TheAM,
  title={The aged monkey basal forebrain: rescue and sprouting of axotomized basal forebrain neurons after grafts of encapsulated cells secreting human nerve growth factor.},
  author={Jeffrey H. Kordower and Shelley R. Winn and Yao Tung Liu and Elliott J. Mufson and John R. Sladek and Joseph P. Hammang and Emmanuel E. Baetge and Dwaine F. Emerich},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1994},
  volume={91 23},
  pages={10898-902}
}
Six Rhesus monkeys between 24 and 29 years of age received unilateral transections of the fornix. Three monkeys then received intraventricular transplants of polymer-encapsulated baby hamster kidney (BHK) fibroblasts that had been genetically modified to secrete human nerve growth factor (hNGF). The remaining three monkeys received identical grafts except the cells were not modified to secrete hNGF. Monkeys receiving the fornix transection and control grafts displayed extensive reductions in… CONTINUE READING

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