The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice.

@article{Lefebvre2012TheAM,
  title={The aged microenvironment contributes to the age-related functional defects of CD4 T cells in mice.},
  author={Julie S. Lefebvre and Alexander C. Maue and Sheri M. Eaton and Paula A. Lanthier and Michael Tighe and Laura Haynes},
  journal={Aging cell},
  year={2012},
  volume={11 5},
  pages={
          732-40
        }
}
CD4 T cells, and especially T follicular helper cells, are critical for the generation of a robust humoral response to an infection or vaccination. Importantly, immunosenescence affects CD4 T-cell function, and the accumulation of intrinsic defects decreases the cognate helper functions of these cells. However, much less is known about the contribution of the aged microenvironment to this impaired CD4 T-cell response. In this study, we have employed a preclinical model to determine whether the… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Follicular helper CD4 T cells (TFH).

  • Annual review of immunology
  • 2011
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Aging of the CD4 T Cell Compartment

  • Open Longevity Science
  • 2012
VIEW 2 EXCERPTS